![]() While TAG Heuer is known for its connection to racing, this line of watches shows that the brand in versatile and can be a part of any market. ![]() The TAG Heuer Aquaracer is the brand’s version of a dive watch. ![]() TAG Heuer Formula 1 $1,450 – $3,200 TAG Heuer Aquaracer This watch has a brand new listing price of $3,200. Its bracelet is steel and brushed black ceramic. It has three chronograph counters and a tachymeter scale on the bezel and also has a power reserve of 42 hours. CAU2011.BA0873 is the most expensive of the Formula 1 models. This watch also has a quartz movement that has a service life of at least 2 years. It also has a tachymeter scale that helps the wearer measure time elapsed. It has a date wind and small seconds subdial at 6 o’clock. WAU1113.BA0858 is the most affordable of the TAG Heuer Formula 1 watches, with a brand new watch listed at a price of $1,450. The TAG Heuer Formula 1 Grande Date 42mm ref. This line is inspired by the McLaren Formula 1 team and is worn by many champion drivers. The TAG Heuer Formula 1 line of watches is the most affordable of the TAG Heuer watches. If you have a TAG Heuer watch or you are interested in purchasing one, you may be asking “How much is my TAG Heuer worth?” Here, we take a look at the prices of each of the brand new TAG Heuer watch models. Whether you have a low budget or if money isn’t a concern, there is most likely a TAG Heuer for you. TAG Heuer watches are very sporty and durable and range in prices. TAG Heuer watches are recognized for their chronograph functions because they are meant to be used to measure time elapsed during each lap of a race. It is often associated with racing as Heuer has been creating timers for racecar dashboards for several decades and TAG Heuer is often associated with Formula 1 racing and many of its drivers. TAG Heuer watches are one of the most affordable brands in the luxury watch market. TAG Group and Heuer combined in 1985 to create the TAG Heuer that we know today. TAG Heuer stands for Techniques d’Avant Garde, which refers to the brands innovative and unique watch designs. All pictures were taken by MD Watches.The worth of a TAG Heuer watch is determined by many factors, including the brands prestige. The pictures show the actual watch you are buying. Manuals, papers, certificate cards, booklets and boxes are only included in the delivery if mentioned in the description and/or shown in the pictures. Item and accessories will be delivered as pictured. Incoming payments are checked several times daily via online banking and are forwarded to be shipped immediately. Your order will be dispatched with DHL within the next working day or within 36 hours after your payment has been received respectively. ![]() Immediate after your purchase, you will receive all payment information by e-mail. The shipping cost is supported by the customer and will be added on the invoice. We are shipping our watches worldwide using insured shipping and only the most reliable shipping service by DHL. Please note that goods will only be sent after agreed payment is visible into our account. We accept payments by wire transfer to our company’s bank account, by PayPal or by credit card (VISA, MASTERCARD, etc.). The recent comparable model of TAG HEUER FORMULA 1 CALIBRE 16 automatic and original TAG Heuer strap has a retail price of 2,750.- Euro.Īlso note the use of alternating polished and brushed surfaces, which helps lift the feel of the watch substantially. We guarantee that all the parts are original TAG Heuer.Ĭase: Fine-brushed and polished steel black PVD coatedĭial: Black, Rhodium plated luminescent indexesīracelet: Rubber, Pin buckle, Fine-brushed steelĬrystal: Scratch-resistant sapphire crystalĬhronograph : 1/4 second, 30 minutes counter, 12 hours counter, Dateīezel: Fixed, Fine-brushed and sandblasted steel black PVD coated, Tachymeter scale This watch comes with papers, but NO box. We guarantee that the item we are selling is an original TAG Heuer watch. ( for price evaluation please consider below information) Comparable manufacturer suggested retail price (MSRP): 2,750.- Euro
0 Comments
This becouse with the new title ID will be so much problem with so much homebrew. Return to Hackmii Installer 1.0 (there is already the link in ) Now is possible to download Hackmii Installer 1.0 or Hackmii Installer 1.2 Now in guide will be used 1.2įorm this release it work without problem also using XP home edition HackMii Installer 1.0 link seek removed by TT. Fix an issue in tutorial about Hackmii Installer Now finalyy WiiDownloder will use Hackmii Installer 1.2 Probably fixed a problem with WIndows Vista SO Now WiiDownloader works without any problem with every Windows version (32 bit and 64 bit) Finaly fixed an issue with Windows Vista: Fixed a possible problem when progarm is in folder withn't ANSI format Code clean and slight increase in the speed of execution of external programs Now also wilbrand works if launched in a folder withn't ANSI format (like Chinese characters) removed use of sharpii: Now I use only NUSD.exe, all download wad from NUS in cache will be re-downloaded (the MD5 is different) Increase time for create cIOS with ModMii to 5 minutes. Test version for understand a problem with some antivirus Little speed increase when used external program Little graphics change in "About your wii." form Now recomended cIOS include d2x-v10-beta52 (no more v8-final) Increased time for download before time-out warning (now 25 seconds of inactivity). Download function now, check filesize less frequently, to use less memory. Now, one first problem in a download, the program try to redownload it automatically Now Wilbrand will not be selected in tutorial if MAC address isn't write Added MD5 check for ModMii.zip download Added a warning message in Editor Mode (only for download from NUS) Changed function for search link in bootmii or mediafire "Probably" NO MORE RELEASE (if no one have problem with this obviously) ![]() Added NaxoR93 in credits for translations Changed function for execute external program Changed function for get file name to download in Editor ![]() The model can potentially be used to manage and optimize pre-harvest and storage practices that will maximize sweetness and minimize mass loss to meet fruit quality standards along supply chains. Moreover, storage duration was shown to increase fruit mass loss and, to a lesser extent, the sweetness index, while fruit from late harvest dates had higher sweetness at the end of storage. The best scenario in terms of acceptable fruit mass loss and sweetness index was for fruit from water-stressed and low crop-loaded trees, 15 ☌ and 70% relative humidity. The Harvest Cup offers great competition for teams of all levels of play. Teams come from all over the world for this tournament. Teams will play in 7 divisions ranging in ages from 35 and over to 70 and over. Model simulations during storage revealed a trade-off between the two selected quality criteria, which increased with increasing storage temperature and decreasing relative humidity. The Harvest Cup is an incredible Soccer in Sun tournament held over 3 days from October 23 to 25, 2021 in Casa Grande, Arizona. ![]() These experimental results were well replicated by the sub-model outputs. We live for the opportunity to call the un-churched into everyday discipleship with Jesus. ![]() Irrigation intensity was also influential on sugar dynamics, along with storage temperature, with fruit stored at the higher temperature (25 ☌) being sweeter than those stored at lower ones (2 and 15 ☌). We are a family of faith in Jesus Christ. Irrigation level influenced fruit surface conductance to water vapor at harvest, but experimental results point out that this variable may have little influence on fruit mass loss during storage, which was mainly driven by relative humidity in the storage chamber. Sub-models parameters were calibrated through results from experiments carried on during 20, where horticultural practices (irrigation and fruit load) and storage conditions were jointly varied. The three sub-models were integrated into a model capable of calculating a fruit sweetness index and relative water loss during storage, which were selected as nectarine quality criteria. The seasonal course of fruit surface conductance to water vapor, fruit mass loss during storage, and sugar concentration dynamics in fruit pulp were modeled. besides that 10 minutes? never have I ever spent 10 minutes just trying to 'figure out what I want' and even if I wasn't the quickest with deciding 10 minutes is plenty of time for one tender to take care of me whilst the others continue their closing duties idk though I'm not back their I'm just saying what ever leaf life was doing to make that happen successfully could easily be followed by this new harvest location.A new mathematical modeling framework able to simulate the combined effect of fruit growth and post-harvest storage conditions (temperature and relative humidity) on nectarine quality is here proposed. ![]() I could understand if I called in and said 'hey do you think I can make it' and was met with a 'probably not' however I was two feet inside the unlocked building and refused service 10 minutes before closing? well if you close at 8:50 then that's what you need to put as your buissness hours as it's a great inconvenience to believe I have time to make it when it's really just at the discretion of their feeling like. Harvest of Casa Grande Dispensary1860 N Salk Dr Suite B1 - Casa GrandeEvents 32.880935-111.707248 Harvest of Casa Grande Dispensary Upcoming Events No events in this location KINDRED NEWSLETTER Be a part of the Kindred Community. they makes claims of closing at 9 however they leave the door unlocked just to let you know they will not assist you because, well they want to clock out at 9. 1860 N Salk Dr Suite B1 Casa Grande AZ 85122 (520) 350-9880 Next Event No upcoming events Loading Map. this new 'harvest' location didn't seem to wish to follow that model. Harvest of Casa Grande Dispensary Upcoming Events No events in this location KINDRED NEWSLETTER. leaf life held honor and integrity to their claim and were clearly more about putting the customers first, they stated they closed at 9 and they did. Casa Grande AZ 85122 (520) 350-9880 Next Event. tonight was my second time coming to this location since the harvest buy out (which I had no love or hate for as harvest is another location I'm quite fond of) however tonight I was turned away at the door 10 minutes before closing.I was a little taken back by this, considering my prior engagement would typically take me up until 8:30 then I would rush to lead life and at some times I would make it 3 minutes before closing and there wasn't even a hesitation on being taken care of. always good quality always great service and always a compassionate and personable crew. it wasn't my main spot but I have certain engagements in casa grande so it was convenient location for me to pop into and whenever I did I was NEVER disappointed. BUY 2 GET 1 FREE! Navy Blue Lime Green Digital Paper,Navy Sexy & trendy Heels at the BEST prices online. ![]() Nina features footwear, shoes, sandals, pumps, wedges and boots for evening, special occasions, wedding, bridal, Explore Glam Pretty Events's board "NAVY BLUE ROSE GOLD WEDDING", followed by 352 people on Pinterest. Navy Satin Pointy Toe Pump Low Heel with Oversized Brooch. ladies Navy For the warmer months opt for espadrilles or cosy up in a pair of slippers. 5'' Solid Tires, Up To 17 Miles Long Range, Electric Scooter for Adults with Dual Braking System Mikey's Motors in Murfreesboro and Mikey's Motors and Golf Carts of Franklin, TN feature new and used utility vehicles & golf cars for sale, apparel. Our wide range of bestselling styles includes strappy heeled sandals, classic courts and elegant kitten heels. Stay on trend with clear straps and feature heels Shop Stylish & Comfortable Silver Heels Today. There’s lots to love about the most serene shade of all, so find blue wedges in classic navy colours and bright pops of blue Haute Couture Navy Blue Leather Mid Heel Loafers Pumps Silver and Gold Metal Accent 7 1/2 AAAA By Salvatore Ferragamo Made in Italy. 00 My Bag Your shopping bag is currently empty. ![]() Kitson Heel in Ivory Leather + 4 colours 30% off at Free shipping BOTH ways on navy blue satin heels from our vast selection of styles. ![]() Women's Strappy Straps Lace Up Chunky Heel Sandals 1,373 +10 Ankis Nude Black Silver Gold Heels for Women Open Toe Ankle Strap Chunky Heel Pump Sandals Party Wedding Strappy Buckle Sandals Standard Size 2. Duluth Airshow is a one-of-a-kind event, lasting from 9 am to 6 pm. OPI Nail Lacquer in Less is Norse – this professional blue 1 - 60 of 191 displayed. Shop the edit of silver shoes by premium brands Steve Madden, Ted Baker and Dune London. If you never used cigarettes other than at the very beginning and saved and loaded at the mine to get the missables: place the roman candle in the snow, use the lighter on itĪCHIEVEMENT UNLOCK: Goodby Windy Oaks (storyline, cant miss) move left then rigth, the location with the toilet where you seen the monster few moments ago return to your car again, use firecrackers on your car, then use the lighter on it move to right, you will see the monster so you pushed back automatically to your previous location you need to light up the 2 bottom ones.ĪCHIEVEMENT UNLOCK: Mayday (storyline, cant miss) on the right side of radion there are 4 panels what you can light up to change frequency to the marked one. set the dials to (from left to right): L, W, T read the notes, solution for radio listed there return to back room inside the visitor center move forward until you reach the bars, use the screwdriver and move outĪCHIEVEMENT UNLOCK: Fresh Air (storyline, cant miss) use the pickaxe on the wall (bricks) to your right return to the spot where you used thermite back out twice, after that you can go to any direction, you should end up at the elevator anyway after 5-7 moves search the clothes (located on the wall) to get a keycard tunnel labyrith tour: right, left, right, straight and left remove tapes, inspect lock, use thermite on it and then the lighterĪCHIEVEMENT UNLOCK: Clever Solution (storyline, cant miss) ![]() combine iron oxide and aluminium dust in your inventory to get thermite (but you know this already if you watched big bang theory s09e03)ĪCHIEVEMENT UNLOCK: Whack-a-mole (missable) use your hatchet on the mine cart to get some iron oxide ![]() look in the hole, located on the wall and take the screwdriver and try to avoid getting heart attack read the sign-note to get knowledge about thermite use lighter on cigarettes in your inventoryĪCHIEVEMENT UNLOCK: Underground Rebel (missable)ĪCHIEVEMENT UNLOCK: Chain-Smoker (missable) This area should have a no smoking sign. read note if you wish, then pick up lantern, combine it with voda then lighter in inventoryĪCHIEVEMENT UNLOCK: Downward Spiral (storyline, cant miss) go back where you cut out damaged tree and move to left, where you should find a large oak tree if you return to backroom now you can see that you need a key card to enter next room head back to the generator, use gasolineĪCHIEVEMENT UNLOCK: Zeus (storyline, cant miss) use rubber hose on the gas tank of your car, then use empty bottle on it enter visitor center, pick up water bottle and check the notes move to the rigth, up the stairs back to the visitor center orange item will fall down, examine it, you will get a key walk back twice, use the hatchet on the damaged tree interact with the generator, its out of gas open the panel of the small building and take the rubber hose pick up rock and use it to break windshield, then go outside open glove box, interact with the coupon and take the casette from thereĪCHIEVEMENT UNLOCK: Welcome to Windy Oaks (storyline, cant miss) ![]() Really Free, no hidden charges, no registration, simply install, play and enjoy!Ĭheck out for extra secrets and techniques about Forgotten Hill.-Take cigarettes and combine it with your lighter in your inventory (move mouse to the top of the screen to see inventory) NEVER DO THIS AGAIN, else you will miss an achievement First chapter of the story of Forgotten Hill, begin losing yourself into its mysteries. Improved controls and extra clear hints Available in 8 languages: English, Spanish, Portoguese, French, German, Italian, Russian and Korean! Solve the puzzles by discovering clues and utilizing your intuition to escape the home in the first chapter of this thrilling journey escape sport. Or perhaps you might simply find your self making an attempt to escape from the horrors that lurk inside. Maybe you can find some assist in that house up on the hill. Your automobile has damaged down and you find yourself looking out for assist alone in the woods, on a chilly November evening, near Forgotten Hill village. Solve puzzles and riddles to escape the home in this thrilling escape recreation. ![]() Roble Holy Kingdom: Calca Bessarez, Kelart Custodio, Neia Baraja, Remedios Custodio. A 2 B 3 C 3 D 2 E 3 G 2 H 1 K 1 L 4 M 2 N 4 P 2 S 3 U 1 W 1 Y 1 Z 1 ALL. ![]() Slane Theocracy: Nigun Grid Luin, Zesshi Zetsumei, Belius, Londes Di Camp, Kaire. All characters in Overlord including Albedo, Narberal Gamma, Shalltear Bloodfallen, Sebas Tian, Lakyus Alvein Dale Aindra and many more. Baharuth Empire: Jircniv Rune Farlord El Nix, Fluder Paradyne, Baziwood Peshmel, Nimble Arc Dale Anoch, Leinas Rockbruise, Nazami Enec, Osk, Go Gin. The Human Kingdoms characters Re-Estize Kingdom: Ramposa III, Renner Theiere Chardelon Ryle Vaiself, Zanac Varleon Igana Ryle Vaiself, Barbro Andrean Ield Ryle Vaiself, Gazef Stronoff, Climb, Philip, Pluton Ainzach, Theo Rakheshir, Panasolei Gruze Day Rettenmaier, Lizzie Bareare, Nfirea Bareare, Brita, Enri Emmot, Nemu Emmot, Goblin Troop, Elias Brandt Dale Raeven, Brain Unglaus, Tuareninya Veyron, The Rogue Lockmeyer. Seven of the Eight heroes who slew the previous overlord, as the years passed they grew complacent in their fame and succumbed to the Seven Deadly Sins.Various Monsters and Creatures Used by Nazarick Main Characters Momonga Tags Analytical Elemental Powers Hat Lightning Powers Magic User Necromancer Person in a Strange World Skeleton Staff Wielder Summoners Teleportation Powers Video Gamer jp. Overlord Isekai overlordseason4 ainzooalgown Hi guys, this is the video of OVERLORD which win the ISEKAI contest we did in our community.Nazarick NPCs characters Floor Guardians. The premise of Log Horizon is really similar to that of Overlord in that they both feature characters stuck in an RPG game with no way out, falling neatly in the Isekai niche. This article describes the characters of Overlord, a series for the Xbox 360, PlayStation 3 and PC video game developed by Triumph Studios and published by Codemasters, consisting of Overlord in 2007, its 2008 expansion Overlord: Raising Hell and Overlord II in 2009. Overlord is an action, adventure, drama, comedy, dark comedy, fantasy, dark fantasy, science fiction, science fantasy, Isekai, fanservice, Japanese anime series.An office worker in a dystopian world logs onto a video game for the last time only to find out that he, along with his entire guild, has been transported to another reality. Warning: Spoilers lay ahead so tread carefully. Overlord: With Satoshi Hino, Chris Guerrero, Yumi Hara, Masayuki Katô. ![]() The realm of Overlord is filled with a bundle of interesting and unique characters that can't possibly fit in one page so we spread them out. ![]() Users whose Azure Active Directory (Azure AD) account is linked to an existing Teams, Microsoft 365, or Office 365 service plan will be able to use that account to sign in to their existing licensed version of the Teams service. When the user launches the Teams client app, they'll be prompted to sign in. Office LTSC 2021 includes the Teams client app. ![]() For more information, see Microsoft Lifecycle Policy. There won’t be any Extended Support available for these products after the five years of Mainstream Support ends. Office LTSC 2021, including Project and Visio, have five years of Mainstream Support. Even though the article isn’t specifically for Office LTSC 2021, the information covered in the article about how the policy settings work does apply to Office LTSC 2021. But that's not considered a change because that policy setting is already available for volume licensed versions of Office 2019.įor more information, see Use policy settings to manage privacy controls. The “Allow the use of additional optional connected experiences in Office" policy setting is also available for Office LTSC 2021. The following are changes in Office LTSC 2021 compared to the volume licensed version of Office 2019. For more information, see Deployment guide for Office for Mac. For more information, see System requirements for Microsoft 365 and Office.įor devices running macOS, Office LTSC Standard for Mac 2021 is available for volume licensed customers. Office LTSC 2021 is supported on devices running Windows 10 or Windows 11. But, how you activate these Office products – for example, by using Key Management Service (KMS) – remains the same. These Office products use Click-to-Run, instead of Windows Installer (MSI), as the installation technology. ![]() The following volume licensed Office products are available for devices running Windows: Office LTSC 2021 is available for enterprise admins to download and deploy to the users in their organization. Microsoft 365 Apps for enterprise already has all the features that are included in Office LTSC 2021, along with many more features that aren't in Office LTSC 2021. For example, if you've deployed Microsoft 365 Apps for enterprise to the users in your organization, you don't need Office LTSC 2021. ![]() Click Close when the installation is complete.Office LTSC 2021 is separate from Office that's available through Microsoft 365 (or Office 365) plans.Click Continue and follow the on-screen instructions to install.If you get an error that the file can't be opened because it's an unknown developer, wait about 20 seconds, drag the file to your desktop, and then hold the Control key as you click the file to open it.Open your Downloads folder and double-click the file called something similar to Microsoft Office-Installer.pkg.If you haven't yet purchased Office, click Buy Office at the top-right corner first, and then follow the on-screen steps to make your purchase.If you don't see this option and are signed in through a business account, go to instead. This is usually your Microsoft account, but if you got Office through your employer or school, you may need to use that account info. If you're not signed in, click Sign in to sign in with the account associated with Office. X Trustworthy Source Microsoft Support Technical support and product information from Microsoft. If you haven't already done so, you'll need to install and redeem Microsoft Office before you can activate it. Starting with just 6 Elements (no, not just 4) and combining them using your skills, wits and knowledge, you will unlock 1700 more and 26 Realms.ĭo you think you can you discover: Atomic Energy, Zeppelin, Chuck Norris, Atlantis or even ‘Angry Birds’ ? You are tasked with rebuilding the universe, bit by bit, or rather Element by Element. *** 3rd best reviewed game on WP7 ! Thanks !!! ★★★★★ All you Lumia 810 owners out there, do yourself a favor and replace that lame duck camera software that came with the phone. ★★★★★ I am genuinely impressed with just how brilliant this application is. ★★★★★ Beautiful app, love the design and filters! ★★★★★ What an app! This allows absolute control over the camera and is a quality app. ★★★★★ Amazing app showcasing the Nokia imaging SDK You also have a favorite button which you can use for one of your favorite actions. 8 modes: Manual, Program, Portrait, Macro, Scenic, Custom 1-3 Pick photo from library menu item in the photo viewer Grids: Rule of thirds, golden ratio, square, Golden spiral ![]() ![]() High resolution support (Nokia Lumia 1020/1520) Fun effects (Mirror, Mono colors and more) Real-time filter effects (Vintage, Nashville, Green Pop, 1977, Lomo, Early Bird, Valencia, Amaro, Hudson and more) It containts a fully featured photo editor that allows to edit effects of existing photos and to undo effects of photos that have been taken by OneShot OneShot combines real-time photo effects with photo editing. Apply a change, such as a filter, and you can see the difference on your screen in real time. OneShot is a professional mobile camera app and offers high quality filters in a lovely user interface that is overlaid on top of your viewfinder. Dictionary works on tablets and phones and is refreshingly free from annoying ads and paid upgrades. There is also a "word of the day" with our pick of the most interesting and entertaining words in the English language. And we managed to keep data offline without needing a massive app download. It also works well if you only have an intermittent network connection because the definitions are stored offline, locally on the device. You can see your word history and revisit definitions, or make your own list of favourite words to help build up your vocabulary. The speech function helps provide the correct pronunciation. Definitions include synonyms and antonyms which allows the dictionary to also serve as a thesaurus. Wildcard characters can be used to help with word games like crosswords and scrabble where only some of the letters are known, or you have to find an anagram, or with spelling. Then you can follow the links in the definition page to get more word definitions. As you type, Dictionary homes in on the word you are looking for. The home page contains a randomly selected word cloud which will pique your curiosity and help you improve your vocabulary, while the search box allows you to find specific words easily. The dictionary definitions are stored locally, and because it's ad-free there's no need for a network connection. Dictionary is ideal for both native English speakers and English learners or people studying the English language. (Requires Windows Phone version 7.5 Mango+)ĭictionary is a free offline English dictionary containing over 200,000 words and definitions and no ads.
However, Hughes notes that because “secret taping has become a lot easier in the age of the smartphone,” he “wouldn’t be surprised if we find out that there are other recordings of presidential conversations.” 7. “I think we as citizens deserve to have an accurate record of presidential deliberations.” “I wish that it was the law that presidential meetings had to be tape recorded,” Hughes says. Prolonging a war for political gain is an abuse of government power, but there was no proof that Nixon had done this until the transcripts became public. If we do, it’s going to hurt us very badly.” “We can't have it knocked over-brutally-to put it brutally-before the election,” he said and Nixon responded, “That's right.” In the last months before the election, Nixon told Kissinger, “South Vietnam probably can never even survive anyway” and “I don’t want it before the election with a Thiệu blowup. Kissinger mentioned this to Nixon as far back as March 1971. But he also knew that this would probably hurt his reelection chances in 1972-which is why he delayed withdrawal until 1973. Nixon knew that he couldn’t win the Vietnam War, and that as soon as American troops pulled out, Nguyễn Văn Thiệu’s U.S.-backed government in the south would fall to the north. 'I don’t want it before the election with a Thiệu blowup.' which certainly was not justified, and was an abuse of governmental power.” 6. “In many ways, Nixon exaggerated what the Kennedy’s did… But at the same time, President Kennedy and Robert Kennedy did approve wiretaps of Martin Luther King Jr. ![]() “In Nixon’s view the Kennedys, both John and Robert, got away with abuses of power that Nixon could not get away with,” Hughes says. Nixon then ranted about the kind of public image his staff should project for him. “His staff created the impression of warm, sweet and nice to people, reads a lot of books, a philosopher and all that sort of thing. “Kennedy was cold, impersonal, he treated his staff like dogs, particularly his secretaries and the others,” Nixon said. 'We really slobbered over that old witch.' When the plumbers-so called because they fixed leaks-discovered military analyst Daniel Ellsberg had released the Pentagon Papers, they broke into his psychiatrist’s office to try to find information to use against him. “He created the ‘plumbers,’ this illegal, unconstitutional secret police organization that he ran out of the White House to counteract the imaginary conspiracy against him.” In response to this conspiracy, Nixon “created a counter conspiracy of his own,” Hughes continues. After the leak of the Pentagon Papers in 1971, he became convinced that that leak was part of a conspiracy that was going to leak his own secrets.” “He believes that members of all those groups are arrogant and that they put themselves above the law. ![]() ![]() “There are three groups about whom Nixon is particularly paranoid: Jews, intellectuals and Ivy Leaguers,” says Ken Hughes, a University of Virginia Miller Center researcher who’s written two books on Nixon’s tapes. ![]() The primary outcome for this analysis was the net clinical outcome (NCO), a composite of stroke/systemic embolism events, major bleeding, or death. Methods ENGAGE AF-TIMI 48 was a multicenter randomized, double-blind, controlled trial in 21,105 patients with atrial fibrillation (AF) within 12 months and CHADS2 score >2 randomized to higher-dose edoxaban regimen (HDER) 60 mg/reduced 30 mg, lower-dose edoxaban regimen (LDER) 30 mg/reduced 15 mg, or warfarin and followed for 2.8 years (median). ![]() Food may have a modest effect on the pharmacokinetic properties of edoxaban.īackground: To compare the efficacy and safety of edoxaban vs. The 2 products of edoxaban tablets are bioequivalent and safe in healthy Chinese volunteers. Both formulations displayed comparable safety profiles, with no serious adverse events reported. ![]() Food increased exposure and prolonged the time to maximum concentration of edoxaban. The geometric least‐squares mean ratios for Cmax, AUC from time 0 to the last measurable time point (AUC0‐t), and AUC from time 0 extrapolated to infinity (AUC0‐∞) were 97.0%, 95.4%, and 96.1%, respectively, in the fasting test, and 98.6%, 100.0%, and 99.8%, respectively, in the fed test. The pharmacokinetic parameters maximum concentration (Cmax) and area under the concentration‐time curve (AUC) were compared to assess bioequivalence. Plasma edoxaban concentrations were determined using liquid chromatography–tandem mass spectrometry. All subjects randomly received 60‐mg generic (test) or branded (reference) edoxaban tablet in each period. Sixty‐four healthy Chinese subjects participated in this open‐label, randomized, 2‐sequence, 4‐period, crossover study. The aim was to investigate the bioequivalence of 2 orally administered edoxaban 60‐mg tablets and the food effects on the pharmacokinetics of edoxaban. ![]() While the relative risk reductions remain similar, edoxaban provides incrementally larger absolute reductions in outcomes over warfarin in patients with higher CHA2DS2VASc scores. The benefit and safety of edoxaban versus warfarin is maintained across CHA2DS2VASc scores. Because of higher event rates the number of events prevented with edoxaban tended to be greater in patients with higher CHA2DS2VASc scores. Edoxaban reduced SSE, MB, ICH, and cardiovascular mortality vs warfarin to a similar degree across the range of CHA2DS2VASc scores (p-int=0.90, 0.96, 0.21, and 0.37, respectively). TTR in warfarin-treated patients was similar and high (median 68-69%) across CHA2DS2VASc scores, whereas edoxaban trough concentration, exogenous anti-FXa activity and %inhibition of endogenous FXa were higher at increasing CHA2DS2VASc scores. Increasing rates of SSE (1.05→2.99%/year) and MB (2.27→4.66%/year) were observed in the warfarin arm as the CHA2DS2VASc score increased. We classified patients based on CHA2DS2VASc score and compared pharmacokinetics (edoxaban concentration), pharmacodynamics (anti-factor Xa with edoxaban, time-in-therapeutic range for warfarin), efficacy (stroke or systemic embolism ), safety (major bleeding, intracranial hemorrhage ), and cardiovascular mortality, for the approved edoxaban regimen vs warfarin. The ENGAGE AF-TIMI 48 trial randomized patients with atrial fibrillation to once-daily edoxaban or warfarin. The efficacy and safety of the oral factor Xa inhibitor edoxaban compared to warfarin stratified by CHA2DS2VASc scores have not been described. |
Details
AuthorWrite something about yourself. No need to be fancy, just an overview. ArchivesCategories |